The hotel lies in the center of a lively area, in the vicinity of Anthony Quinn Bay, The Water Park and Filerimos.
The city center is 20 minutes' walk of the property. Thanks to a port nearby, the hotel is well connected with other parts of Afantou.
The property comprises of modern rooms, including Triple Room and Double Room appointed with a balcony, a refrigerator, wireless internet, climate control and a wardrobe. Guests will enjoy a view of the Cretan Sea from their rooms. The guestrooms offer a traditional interior and marble floor.
A breakfast is served in the dining area. The seaside restaurant provides fine meals. Indoor bar is available on site. Guests can dine in Mimakos located within a 10-minute walk of the property.
Diagoras airport can be reached in 15 minutes by car from Despina Hotel.
The on-site car rentals are also provided.
The hotel offers a playground and a pool for guests with children.